An increasing number of cases of multi-drug resistant tuberculosis and total-drug resistant tuberculosis are being discovered in India, accounting for the highest TB burden in any country across the globe. It has been said, ‘It is not the strongest species that survive, nor the most intelligent, but the ones most responsive to change’. Mycobacterium tuberculosis is able to adapt and thrive despite the immune system and drugs that are targeted against it. This is due to its ability to sense and adapt to its host's environment. Dr. Deepak Saini’s laboratory at the Indian Institute of Science, Bangalore, is working at unraveling the molecular mechanism that helps M. tuberculosis sense, respond and adapt to its host environment.
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Among viruses, the Hepatitis C virus is extremely persistent – a patient sometimes cannot get rid of the virus after infection, and it remains in their cells over long periods of time. The standard HCV treatment is effective over time only in half the patients, making Hepatitis C the bane of doctors and scientists worldwide. Researchers at the Therapeutic Engineering Lab at the Department of Chemical Engineering, Indian Institute of Science, think they may know more about why the disease is persistent. Using simulations, they found that the Hepatitis C virus and the body’s immune system get into a deadlock when the body is fighting the virus.
Here is a possible addition to medical technology: a tiny needle, about a thousand times thinner than the thinnest hospital syringe available today. The needle can pierce the skin and deliver drugs directly into the body.
The hepatitis C virus is one of the main causes of chronic liver disease, which can lead to liver fibrosis, cirrhosis and hepatocellular carcinoma. Around 170 million people are infected with the virus worldwide. Compounds isolated from the extract of Pomegranate peel inhibit the growth of the hepatitis C virus (HCV), a recent study has found.